Effect of salicylidene salicylhydrazide on testes of albino mice: A histomorphological study.

Objectives: To evaluate salicylidene salicylhydrazide (SCS) for any possible toxicological effects on male reproductive system in Albino BALB/c mice. Study Design: Experimental study. Setting: Department of Histopathology, Khyber Medical College Peshawar and Pharmacy, University Peshawar, were utilized conducting this Period: July, 2020 to December, 2020. Material & Methods: Male mice daily administered with SCS at 5, 25, 50 mg/kg 7 14 days. The body testes weights measured the subjected histological tissue processing techniques. Results: extent testicular toxicity was evaluated by using modified Johnsen scoring assessing level spermatogenesis, morphometric analysis measuring diameter seminiferous tubules, thickness germinal epithelium, area interstitial cells Leydig. showed that various doses have no substantial after tested did not produce distinguishable change normal features tubules interstitium However, days, dose associated vacuolization loosening epithelium. These mild-to-moderate histopathological aberrations confirmed from group which a decrease tubules’ reduction epithelium along an increase observed. Conclusion: findings concluded is considered be relatively safe.